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Gultekin O, Gonzalez-Molina J, Sarhan D, Groes-Kofoed N, Hassan MU, Lehti K, Salehi S

The study was conducted in accordance with the Declaration of Helsinki and with the approval of the City of Hope Internal Review Board (IRB #13447)

4.3 Oxidative stress Oxidative stress can act as an important link between angiogenesis and inflammation and has been demonstrated to be associated with multiple neurological diseases, such as stroke, traumatic brain injury, Alzheimers disease, Parkinsons disease, Huntingtons disease, and multiple sclerosis

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In cytokine-stimulated astrocytes, arginine deprivation activates the amino acid-sensing kinase GCN2, leading to phosphorylation of eukaryotic initiation factor 2 (eIF2) and suppression of iNOS protein synthesis, thereby attenuating NO production